全文获取类型
收费全文 | 189271篇 |
免费 | 17951篇 |
国内免费 | 8329篇 |
专业分类
耳鼻咽喉 | 2557篇 |
儿科学 | 3945篇 |
妇产科学 | 2018篇 |
基础医学 | 35688篇 |
口腔科学 | 5985篇 |
临床医学 | 15053篇 |
内科学 | 25162篇 |
皮肤病学 | 4562篇 |
神经病学 | 12419篇 |
特种医学 | 4987篇 |
外国民族医学 | 119篇 |
外科学 | 17709篇 |
综合类 | 28266篇 |
现状与发展 | 52篇 |
预防医学 | 5152篇 |
眼科学 | 4051篇 |
药学 | 15178篇 |
28篇 | |
中国医学 | 5818篇 |
肿瘤学 | 26802篇 |
出版年
2024年 | 154篇 |
2023年 | 2631篇 |
2022年 | 3352篇 |
2021年 | 6417篇 |
2020年 | 6157篇 |
2019年 | 5951篇 |
2018年 | 6153篇 |
2017年 | 6401篇 |
2016年 | 6623篇 |
2015年 | 7518篇 |
2014年 | 11078篇 |
2013年 | 12364篇 |
2012年 | 10592篇 |
2011年 | 11885篇 |
2010年 | 9902篇 |
2009年 | 9490篇 |
2008年 | 9968篇 |
2007年 | 10273篇 |
2006年 | 9337篇 |
2005年 | 8507篇 |
2004年 | 7638篇 |
2003年 | 6728篇 |
2002年 | 5515篇 |
2001年 | 4756篇 |
2000年 | 3936篇 |
1999年 | 3443篇 |
1998年 | 2906篇 |
1997年 | 2860篇 |
1996年 | 2472篇 |
1995年 | 2516篇 |
1994年 | 2243篇 |
1993年 | 1905篇 |
1992年 | 1605篇 |
1991年 | 1517篇 |
1990年 | 1212篇 |
1989年 | 1126篇 |
1988年 | 1038篇 |
1987年 | 852篇 |
1986年 | 762篇 |
1985年 | 1025篇 |
1984年 | 906篇 |
1983年 | 613篇 |
1982年 | 706篇 |
1981年 | 585篇 |
1980年 | 483篇 |
1979年 | 379篇 |
1978年 | 301篇 |
1977年 | 247篇 |
1976年 | 207篇 |
1975年 | 81篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
994.
995.
996.
997.
Ochratoxin A (OTA) is a mycotoxin that mainly causes nephrotoxicity. The single nephrotoxicity of OTA exposure on glomeruli or renal tubule had been well documented, however, the comparison toxicity between it is still unclear. Here, C57BL/6 mice and two types of nephrocyte were treated with concentration-gradient OTA to explore its differentiation nephrotoxicity. Results showed that OTA induced nephrotoxicity in vivo and in vitro, manifested as the deteriorative kidney function in mice and the cut-down cell viability in nephrocyte. Besides, results of murine kidney pathological section and IC50 of two types nephrocyte indicated that OTA-induced toxicity in renal tubule was higher than its in glomeruli. In addition, OTA exposure induced autophagy signaling differentiation expression. It revealed that autophagy was implicated in OTA-induced differential nephrotoxicity in glomeruli and renal tubule. Altogether, we proved that OTA induces a differentiation nephrotoxicity in glomeruli and renal tubule, and it is related to autophagy differential regulation. 相似文献
998.
《International journal of oral and maxillofacial surgery》2022,51(3):314-322
While Merkel cell carcinoma (MCC) of the head and neck is highly malignant, it remains poorly characterized due to its rarity. The purpose of this study was to examine prognostic factors for overall survival (OS) and disease-specific survival (DSS) in patients with MCC of the head and neck region. The Surveillance, Epidemiology and End Results registry was reviewed for patients diagnosed between 1984 and 2016 with histologically confirmed, primary MCC of the head and neck region. A total of 2818 patients met the inclusion criteria, with a median age at diagnosis of 77 years. At five and 10 years, respectively, the OS was 42.4% and 25.1% and the DSS was 67.9% and 64.1%. Multivariate Cox analysis indicated that predictors of decreased DSS included age at diagnosis ≥75 years, white race, increasing tumor spread, lymph node involvement and either the lip or the scalp/neck as a primary site. When adjusting for the aforementioned factors, tumor depth was not found to be a prognostic factor for DSS. We anticipate these results will help clinicians to counsel patients regarding expectations and potential prognosis. 相似文献
999.
《International journal of oral and maxillofacial surgery》2022,51(6):732-741
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies and has a low 5-year survival rate. Mounting evidence suggests that oral potentially malignant disorders, such as oral leukoplakia (OLK), may progress to HNSCC. Given that OLK and HNSCC are often insidious and asymptomatic, the identification of markers of OLK malignant transformation and therapeutic targets in HNSCC is critical. Using various online tools and publicly available gene expression datasets, the secreted phosphoprotein 1 gene (SPP1) was identified as a significant differentially expressed gene among OLK, HNSCC, and non-cancerous tissues. SPP1 mRNA levels were elevated in HNSCC tissues and were associated with cancer stage, tumor grade, and human papillomavirus infection status. High SPP1 mRNA levels were correlated with poor overall survival of HNSCC patients. In contrast, SPP1 mutations were not significantly associated with overall survival, although their frequency in HNSCC was very low (0.6%). Furthermore, SPP1 expression levels in HNSCC were positively correlated with the infiltration of CD4+ cells, macrophages, neutrophils, and dendritic cells. The study results suggest that SPP1 may represent a diagnostic and prognostic biomarker, as well as a potential therapeutic target in HNSCC. 相似文献
1000.